Using laboratory ferrets and mice, researchers from China and the UK found that humans could be “vulnerable” to infection from the H3N8 strain of bird flu at “epidemic or pandemic proportions”
Scientists have expressed fears over the emergence of another pandemic amid the outbreak of a new strain of bird flu discovered in Chinese poultry farms.
A team of researchers from China and the UK studied a sample of H3N8, which is one of the most common strains in birds but little is known about how it is transmitted to humans. Using laboratory ferrets and mice, they found that humans could be “vulnerable to infection at epidemic or pandemic proportions”.
Paper co-author Professor Jinhua Liu, of the China Agricultural University in Beijing, said: “Importantly, we discovered that the virus had acquired human receptor binding preference and amino acid substitution PB2-E627K, which are necessary for airborne transmission.
“Human populations, even when vaccinated against human H3N2 virus, appear immunologically naive to emerging mammalian-adapted H3N8 avian influenza viruses and could be vulnerable to infection at epidemic or pandemic proportions. Acid resistance of influenza virus is also an important barrier for avian influenza virus to overcome to acquire the adaptability and transmissibility in new mammals of humans.